Every cell in a body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is different ...

Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome.

Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome. Those interactions depend ...

MIT researchers have, for the first time, measured chromatin movement across timescales from microseconds to hours, revealing two distinct motion modes—constrained and freer movement. These dynamics ...

Penn Engineers have developed a new way to use AI to solve inverse partial differential equations (PDEs), a particularly ...

Researchers from the University of Chicago (IL, USA) have reported that unstable, or ‘noisy’, chromatin enables cells to take on different roles in the body. This flexibility can support the immune ...

Previously, linker histone H1 was thought to bind stably to nucleosomes and compact chromatin by forming an ordered, “rigid” structure (left). In this study, we show that H1 binds to nucleosomes ...

Every cell in the human body squeezes over six feet of DNA into a minuscule speck invisible to the naked eye—like compressing ...

Researchers use AI to discover 14 distinct nucleosome states, revealing that DNA packaging acts as a "volume dial" for gene ...